Mark Reimers, Ph. D.
Assistant Professor,
Biosciences,
Karolinska Institute, Stockholm
Mark Reimers, Ph. D.
Assistant Professor,
Biosciences,
Karolinska Institute, Stockholm
Contact Information
Phone: +46-8-608-3333
Fax: +46-8-608-xxxx
Email: Mark.Reimers@biosci.ki.se
My main responsibility is bioinformatics services through the Sequence Analysis Center at the Karolinska Institute, especially data analysis for gene expression microarrays.
My long-term interests are statistical inference about biological systems. The era of high-throughput biology brings us enormous observation sets, and automating inference strategies is important. My belief is that we’ll get better results in such a complex field by incorporating biology into the inference process. My plan is first to build competence in analysis of high-throughput biochemical data, then study inference about gene regulation and protein interaction from such data. Therefore my current research is in statistical methods for gene expression analysis and inference for regulatory networks.
My research is currently focussed on methods for estimating accurate expression values from multiple probe systems such as the Affymetrix system.
·
Model for estimation of expression levels in Affymetrix
arrays, using linear statistical models, with robust parameter estimation.
·
Normalization of single-channel arrays
·
Comparability of platforms: transformations of measures
from one expression platform to another
·
Methods for identifying binding sequences for nuclear receptors
using expression and sequence information (with Hui Gao, CBT, KI )
·
Profiling gene expression in rat models for alcoholism
(with Christina Arlinde and Wolfgang Sommer, Neurotec, KI)
·
Profiling gene expression of parathyroid tumors (with
Lars Forsberg, CMM, KI)
·
Profiling gene expression of thyroid tumors (with
Weng-Onn Lui, CMM, KI)
·
Quality control of the microarray based on the
newly-sequenced organism Schizosaccharomyces Pombe (with Anthony Wright, SHS)